abstract：:Enamel matrix derivative (EMD) is a commercially available protein extract, mainly comprising amelogenins. A number of other polypeptides have been identified in EMD, mostly growth factors, which promote cementogenesis and osteogenesis during the regeneration processes through the regulation of cell proliferation, dif...

journal_title：Experimental and therapeutic medicine

authors： Wyganowska-Świątkowska M,Urbaniak P,Nohawica MM,Kotwicka M,Jankun J

更新日期：2015-06-01 00:00:00

abstract：:The aim of the present study was to investigate the expression profiles of cyclooxygenase (COX)-2 and microRNA (miRNA)-143 in the tumor tissue and blood samples of patients with osteosarcoma, and their involvement in the disease pathogenesis. Tumor tissue and blood samples were obtained from 46 patients with osteosarc...

journal_title：Experimental and therapeutic medicine

authors： Fang Y,Zhang Z,Wang Q,Zhao J

更新日期：2015-06-01 00:00:00

abstract：:The transformation of prostate cancer from an androgen-dependent state to an androgen-independent state is a lethal progression. Alterations in transcriptional programs are the basis of prostate cancer deterioration. The androgen receptor (AR), a member of the nuclear hormone receptor superfamily, mediates prostate ca...

journal_title：Experimental and therapeutic medicine

authors： Cheng Y,Yu P,Duan X,Liu C,Xu S,Chen Y,Tan Y,Qiang Y,Shen J,Tao Z

更新日期：2015-06-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of microRNA (miR)-92a on cystatin C expression in patients with type II diabetes and lower limb ischemia. A total of 199 patients diagnosed with type II diabetes were included in the study and divided into three experimental groups: Simple type II diabetes mel...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Guan Q,Jin X

更新日期：2015-06-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are involved in bone formation in the embryo, bone repair and remodeling. The differentiation of these cells is a complex multistep pathway that involves discrete cellular transitions and is similar to that which occurs during hematopoiesis. MSCs have self-renewal capacity without differe...

journal_title：Experimental and therapeutic medicine

authors： Shima WN,Ali AM,Subramani T,Mohamed Alitheen NB,Hamid M,Samsudin AR,Yeap SK

更新日期：2015-06-01 00:00:00

abstract：:The aim of the present study was to investigate the expression of estrogen receptor β (ERβ) in triple-negative and triple-positive breast cancer patients, and evaluate its utility as a prognostic factor. Between January 2000 and December 2010, primary tumor tissue samples were collected from 234 subjects, including 10...

journal_title：Experimental and therapeutic medicine

authors： Guo L,Zhu Q,Aisimutuola M,Yilamu D,Liu S,Jakulin A

更新日期：2015-06-01 00:00:00

abstract：:The aim of this study was to investigate the effect of lysosomal and ubiquitin-proteasome system dysfunction on the abnormal aggregation of α-synuclein, and to analyze its role in the pathogenesis of Parkinson's disease (PD). PC12 cells subjected to nerve growth factor-induced differentiation were used as the cell mod...

journal_title：Experimental and therapeutic medicine

authors： Wang R,Zhao J,Zhang J,Liu W,Zhao M,Li J,Lv J,Li Y

更新日期：2015-06-01 00:00:00

abstract：:The aim of the present study was to investigate the electrophysiological properties of transient receptor potential melastatin 7 (TRPM7) channels in the cell membranes of cardiac fibroblasts (CFs). CFs obtained from Sprague-Dawley rats were treated with six different concentrations of angiotensin (Ang) II for 12 h. Th...

journal_title：Experimental and therapeutic medicine

authors： Zhou Y,Yi X,Wang T,Li M

更新日期：2015-05-01 00:00:00

abstract：:Pulmonary synovial sarcoma is a rare but aggressive disease. The present study describes the case of a 68-year-old female with pulmonary synovial sarcoma. The patient was mistakenly treated for small cell lung cancer due to false-positive staining for synaptophysin and cluster of differentiation 56. Despite severe mye...

journal_title：Experimental and therapeutic medicine

authors： Satoh H,Takayashiki N,Shiozawa T,Miyazaki K,Ohara G,Kagohashi K,Kurishima K,Sugita S,Aoyama T,Hasegawa T,Hizawa N

更新日期：2015-05-01 00:00:00

abstract：:The aim of the present study was to determine whether chlorogenic acid (CA) is able to modulate cadmium (Cd)-induced oxidative brain damage. Cd-treated rats displayed numerous pathological effects, including the inhibition of acetylcholinesterase, elevated lipid peroxidation, the depletion of enzymatic and non-enzymat...

journal_title：Experimental and therapeutic medicine

authors： Hao ML,Pan N,Zhang QH,Wang XH

更新日期：2015-05-01 00:00:00

abstract：:The aim of the present study was to investigate whether magnolol, the essential component of the traditional Chinese medicine, Magnolia officinalis, can pass through liver X receptor α (LXRα), to subsequently play an important role in the lipid metabolic balance. Using a HepG2 human hepatoma cell line, mammalian cellu...

journal_title：Experimental and therapeutic medicine

authors： Xie NA,Hu C,Guo A,Liang H,DU P,Yin G

更新日期：2015-05-01 00:00:00

abstract：:Achondroplasia (ACH) is a hereditary dwarfism caused by the disturbed proliferation and differentiation of growth plate chondrocytes, followed by impaired endochondral bone growth. ACH is caused by mutations in the gene encoding the transmembrane receptor, fibroblast growth factor receptor 3 (FGFR3). In total, >90% of...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Tang X,Cheng J,Wang L,Yang X,Wang Y

更新日期：2015-05-01 00:00:00

abstract：:In patients with chronic kidney disease (CKD), hypertension (HP) is associated with the development of left ventricular (LV) diastolic dysfunction. However, the impact of antihypertensive treatment on LV diastolic function has not been well studied in CKD patients. Recently, two-dimensional speckle-tracking echocardio...

journal_title：Experimental and therapeutic medicine

authors： Li KL,Wang RX,Dai M,Lu J,Xue J,Yang XJ

更新日期：2015-05-01 00:00:00

abstract：:The host response to spinal cord injury (SCI) can lead to an ischemic environment that can induce cell death. Therapeutic interventions using neurotrophic factors have focused on the prevention of such reactions in order to reduce this cell death. Vascular endothelial growth factor (VEGF) is a potent angiogenic and va...

journal_title：Experimental and therapeutic medicine

authors： Yu H,Lin B,He Y,Zhang W,Xu Y

更新日期：2015-05-01 00:00:00

abstract：:Preeclampsia is a major cause of maternal and perinatal mortality and morbidity, characterized by gestational hypertension, proteinuria, systemic endothelial cell activation and an exaggerated inflammatory response. The precise cause of preeclampsia is not currently known; however, it is widely accepted that the patho...

journal_title：Experimental and therapeutic medicine

authors： Liu X,Dai LI,Zhou R

更新日期：2015-05-01 00:00:00

abstract：:Red cell distribution width (RDW) has been found to be a novel prognostic biomarker in patients with coronary artery disease (CAD); however, the association between RDW and the risk of heart events in patients with CAD is yet to be fully elucidated. Thus, the aim of the present study was to determine whether an elevat...

journal_title：Experimental and therapeutic medicine

authors： Li W,Li X,Wang M,Ge X,Li F,Huang B,Peng J,Li G,Lu L,Yu Z,Ma J,Xu L,Jin M,Si H,Wan R

更新日期：2015-04-01 00:00:00

abstract：:The aim of the present study was to investigate the genes associated with 'anger-in' (tendency to suppress anger) and 'anger-out' (tendency to express anger through verbal or physical means) emotions in humans. Wistar rats were divided into five groups (n=10/group), based on the type of model and the Chinese medicinal...

journal_title：Experimental and therapeutic medicine

authors： Guo Y,Zhang H,Gao J,Wei S,Song C,Sun P,Qiao M

更新日期：2015-04-01 00:00:00

abstract：:Rosai-Dorfman disease (RDD), otherwise known as sinus histiocytosis with massive lymphadenopathy, is a rare disease. Cutaneous RDD (CRDD) is an extremely rare form of RDD, which is limited to the skin. The present study examined a case of purely CRDD in a 25-year-old female patient who presented with a two-month histo...

journal_title：Experimental and therapeutic medicine

authors： Fang S,Chen AJ

更新日期：2015-04-01 00:00:00

abstract：:The hyper-IgM syndromes (HIGMs) are a group of primary immune deficiency diseases characterized by a normal or elevated serum level of IgM and low or absent serum levels of IgG, IgA and IgE. Here, we report a case of X-linked HIGM with a new CD40L gene mutation presenting with eosinophilia. The patient experienced rec...

journal_title：Experimental and therapeutic medicine

authors： Guo LI,Chen BO,Xu B,Lu M,Ning B,Chen Z

更新日期：2015-04-01 00:00:00

abstract：:Shikonin (SK), a naturally occurring naphthoquinone, exhibits antitumor activity. However, its precise mechanisms of action are unknown. In the present study, the effects of SK on NCI-H460 human lung cancer cells were investigated. It was found that SK reduced cell viability and induced apoptosis in the NCI-H460 cells...

journal_title：Experimental and therapeutic medicine

authors： Qu D,Chen YU,Xu XM,Zhang M,Zhang YI,Li SQ

更新日期：2015-04-01 00:00:00

abstract：:The role of contaminated clothing in the transmission of influenza A virus during an epidemic period was investigated by examining the recovery of infectious influenza virus from experimentally virus-contaminated clothing, which had been subejected to routine wearing and washing for several months or years. The amount...

journal_title：Experimental and therapeutic medicine

authors： Ikeda K,Tsujimoto K,Suzuki Y,Koyama AH

更新日期：2015-04-01 00:00:00

abstract：:The aim of the present study was to investigate the therapeutic effect of a combined treatment of Buyang Huanwu decoction (BYHWD), a well-known formula of traditional Chinese medicine, and neural stem cells (NSCs) on spinal cord injury (SCI) and the associated underlying mechanisms. A SCI model was established by surg...

journal_title：Experimental and therapeutic medicine

authors： Zhang M,Chai Y,Liu T,Xu N,Yang C

更新日期：2015-04-01 00:00:00

abstract：:Hydrogen sulfide (H2S) is believed to be involved in numerous physiological and pathophysiological processes, and now it is recognized as the third endogenous signaling gasotransmitter, following nitric oxide and carbon monoxide; however, the effects of H2S on inflammatory factors in acute myocardial ischemia injury i...

journal_title：Experimental and therapeutic medicine

authors： Liu F,Liu GJ,Liu N,Zhang G,Zhang JX,Li LF

更新日期：2015-03-01 00:00:00

abstract：:Sepsis is a serious condition characterized by an infectious process that induces a severe systemic inflammatory response. In this study, the effects of gemfibrozil (GFZ) on the inflammatory response associated with abdominal sepsis were investigated using a rat model of cecal-ligation and puncture (CLP). Male Wistar ...

journal_title：Experimental and therapeutic medicine

authors： Cámara-Lemarroy CR,Guzman-DE LA Garza FJ,Cordero-Perez P,Ibarra-Hernandez JM,Muñoz-Espinosa LE,Fernandez-Garza NE

更新日期：2015-03-01 00:00:00

abstract：:microRNAs (miRNAs) are evolutionarily conserved, endogenous, small, noncoding RNA molecules of approximately 22 nucleotides in length that function as post-transcriptional gene regulators. Their aberrant expression may be involved in human diseases, including cancer. Although miRNA-184 (miR-184) has been reported in o...

journal_title：Experimental and therapeutic medicine

authors： Su Z,Chen D,Li Y,Zhang E,Yu Z,Chen T,Jiang Z,Ni L,Yang S,Gui Y,Ye J,Lai Y

更新日期：2015-03-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase (IDO) is an immunoregulatory enzyme. It plays a key role in various malignancies, infection and autoimmune diseases. IDO induces immunosuppression through the depletion of tryptophan and its downstream metabolites. Hepatitis C virus (HCV) has infected more than 12 million individuals in Pak...

journal_title：Experimental and therapeutic medicine

authors： Asghar K,Ashiq MT,Zulfiqar B,Mahroo A,Nasir K,Murad S

更新日期：2015-03-01 00:00:00

abstract：:Extramedullary T-lymphoblastic blast crisis of chronic myelogenous leukemia (CML) is uncommon and the prognosis is poor. It was usually misdiagnosed as the co-existence of T-lymphoblastic lymphoma (T-LBL) and CML. In the present study, we report a patient with CML, who developed extramedullary T-lymphoblastic blast cr...

journal_title：Experimental and therapeutic medicine

authors： Zeng DF,Chang C,Li JP,Kong PY,Zhang X,Gao L

更新日期：2015-03-01 00:00:00

abstract：:The ChrT gene encodes a chromate reductase enzyme which catalyzes the reduction of Cr(VI). The chromate reductase is also known as flavin mononucleotide (FMN) reductase (FMN_red). The aim of the present study was to clone the full-length ChrT DNA from Serratia sp. CQMUS2 and analyze the deduced amino acid sequence and...

journal_title：Experimental and therapeutic medicine

authors： Deng P,Tan X,Wu Y,Bai Q,Jia Y,Xiao H

更新日期：2015-03-01 00:00:00

abstract：:Diffuse ganglioneuromatosis (DG) of the gastrointestinal tract is a rare condition that is closely associated with neurofibromatosis type 1 and multiple endocrine neoplasia type 2B. The occurrence of DG with multiple schwannomas, which, of the GI tract, usually affect the stomach, is considerably more rare. The presen...

journal_title：Experimental and therapeutic medicine

authors： Lu C,Qiu Y,Lu X,Li G,Bu H

更新日期：2015-03-01 00:00:00

abstract：:The complex network of etiological factors, signals and tissue responses involved in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) cannot be successfully targeted by a single therapeutic agent. Multimodal approaches to the therapy of CP/CPPS have been and are currently being tested, as in the frame of com...

journal_title：Experimental and therapeutic medicine

authors： Magri V,Marras E,Restelli A,Wagenlehner FM,Perletti G

更新日期：2015-03-01 00:00:00

abstract：:The aim of the present study was to clarify the association between lipid metabolism and the atherosclerosis in early-stage chronic renal failure at the molecular level and to explore the efficacy of decorin on chronic renal failure. Sprague Dawley rats receiving 5/6 nephrectomy and Sham surgery were divided into cont...

journal_title：Experimental and therapeutic medicine

authors： Ma HB,Wang R,Yu KZ,Yu C

更新日期：2015-02-01 00:00:00

abstract：:This study aimed to investigate the effect of ambroxol on the concentration of cefotaxime in the bronchioalveolar lavage fluid of rats with bleomycin-induced pulmonary fibrosis. A total of 54 Wistar male rats were randomly divided into three groups, namely the normal control group, model group and ambroxol group. On e...

journal_title：Experimental and therapeutic medicine

authors： Chen F,Zhang YX,Zhang CQ

更新日期：2015-02-01 00:00:00

abstract：:Hericium erinaceus (HEP) is a notable medicinal fungus grown in China and other oriental countries. Polysaccharides from HEP have recently attracted considerable attention due to their numerous physiological activities. The objective of this study was to evaluate the anti-fatigue activity of HEP in a mouse model. Afte...

journal_title：Experimental and therapeutic medicine

authors： Liu J,DU C,Wang Y,Yu Z

更新日期：2015-02-01 00:00:00

abstract：:The aim of this study was to determine the metabolic biomarkers for abnormal Savda syndrome in patients with chronic obstructive pulmonary disease (COPD). Based on Traditional Uyghur Medicine (TUM) theory, a total of 103 patients with COPD were classified into abnormal Savda and non-abnormal Savda syndrome groups and ...

journal_title：Experimental and therapeutic medicine

authors： Xu WF,Upur H,Wu YH,Mamtimin B,Yang J,Ga YJ,You L

更新日期：2015-02-01 00:00:00

abstract：:The aim of the present study was to track in vivo the distribution and survival of adipose-derived mesenchymal stem cells (ASCs) transplanted into female BALB/c nude mice following simulated childbirth injury, using green fluorescent protein and luciferase dual labeling, bioluminescent imaging (BLI) and histological e...

journal_title：Experimental and therapeutic medicine

authors： Dai M,Xu P,Hou M,Teng Y,Wu Q

更新日期：2015-02-01 00:00:00

abstract：:Psoriasis affects 2-4% of the population worldwide and its treatment is currently far from satisfactory. Calcipotriol and Portulaca oleracea have been reported to exhibit the capacity to inhibit inflammation in psoriatic patients and improve their clinical condition. However, the efficacy of a combination regimen of t...

journal_title：Experimental and therapeutic medicine

authors： Zhao H,Li S,Luo F,Tan Q,Li H,Zhou W

更新日期：2015-02-01 00:00:00

abstract：:The aim of the present study was to investigate the association between polymorphism in the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) in the promoter region of the 5-HTT gene and the pathogenesis of postpartum depression (PPD). Blood samples were collected from 120 female patients with PP...

journal_title：Experimental and therapeutic medicine

authors： Zhang X,Wang L,Huang F,Li J,Xiong L,Xue H,Zhang Y

更新日期：2015-01-01 00:00:00

abstract：:The aim of this study was to observe the effects of cluster of differentiation (CD) 151 on the expression of vascular endothelial growth factor (VEGF) in ischemic myocardium by the injection of a recombinant adeno-associated virus (rAAV) vector carrying the human CD151 gene. A rat acute myocardial infarction model was...

journal_title：Experimental and therapeutic medicine

authors： Fu H,Tan J,Yin Q

更新日期：2015-01-01 00:00:00

abstract：:Tartrate-resistant acid phosphatase 5b (TRACP 5b) has been used as a biomarker of bone resorption and cancer metastasis. TRACP 5b has also been suggested to be a reliable marker of osteoclast number. In this study, the correlation of TRACP 5b level and osteoclast-like cell number was investigated in RAW 264.7 cells tr...

journal_title：Experimental and therapeutic medicine

authors： Lv Y,Wang G,Xu W,Tao P,Lv X,Wang Y

更新日期：2015-01-01 00:00:00

abstract：:Postprandial hypertriglyceridemia impairs endothelial function and plays an important role in the development of atherosclerosis. The aim of the present study was to examine the postprandial effects of the dipeptidyl peptidase-4 inhibitor vildagliptin and the α-glucosidase inhibitor voglibose on endothelial dysfunctio...

journal_title：Experimental and therapeutic medicine

authors： Noguchi K,Hirota M,Miyoshi T,Tani Y,Noda Y,Ito H,Nanba S

更新日期：2015-01-01 00:00:00